AddToMe: This page is intended to hold user experiences of running Windows apps under Wine and WineX?.
http://www.frankscorner.org/wine/ is an incredible resource. Check it out for information on running all those difficult applications such as Dreamweaver, Photoshop, MS Office and Nero.
After installing WineX (I already had debian's Wine installed), things (such as sound and graphics) mis-behaved. I found that moving wine's registry files (/.wine/system.reg and /.wine/user.reg) out of the way and letting the new version re-create them fixed the problems, although I needed to re-initialise any apps.
2 pages link to WineNotes: